Phenotypes associated with this allele

• Allele Symbol: Cat4^Apcat1-2
• Allele Name: anisocoria
• Allele ID: MGI:1856586
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cat4^Apcat1-2/Cat4^Apcat1-2	involves: 101 * C3H	MGI:2175742
ht2	Cat4^Apcat1-2/Cat4^+	involves: 101 * C3H	MGI:2175743

Genotype
MGI:2175742

hm1

• Allelic Composition: Cat4^Apcat1-2/Cat4^Apcat1-2
• Genetic Background: involves: 101 * C3H

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:6686 )

• lethal

Genotype
MGI:2175743

ht2

• Allelic Composition: Cat4^Apcat1-2/Cat4⁺
• Genetic Background: involves: 101 * C3H

behavior/neurological

abnormal pupillary reflex ( J:6686 )

• dilated abnormally toward the nasal side after atropine treatment

vision/eye

abnormal pupillary reflex ( J:6686 )

• dilated abnormally toward the nasal side after atropine treatment

anisocoria ( J:9528 )

irregularly shaped pupil ( J:6686 )

• pupils are ovoid

cornea opacity ( J:6686 , J:9528 )

cataract ( J:9528 )

anterior polar cataract ( J:6686 )

• incomplete penetrance; 20% of mice exhibit anterior polar opacity

abnormal eye development ( J:6686 , J:9528 )

• incomplete penetrance; 70% of mice have remnants of the pupillary membrane present at later developmental stages (J:6686)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cataract		DOID:83	OMIM:601371 OMIM:PS116200	J:6686 , J:9528