Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atcayji mutation
(2 available);
any
Atcay mutation
(27 available)
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mortality/aging
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• mice die at 3 to 4 weeks of dehydration and starvation
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behavior/neurological
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• severe truncal and limb ataxia
• at 3 weeks mice are unable to walk or to right themselves
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homeostasis/metabolism
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atcayji mutation
(2 available);
any
Atcay mutation
(27 available)
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mortality/aging
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• as seizures and impaired coordination become more severe, the mice lose the ability to obtain food and die, usually by 4 weeks old, from starvation and thirst
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behavior/neurological
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• animals exhibited difficulty righting themselves after being placed on their backs
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• severe muscle tetany was exhibited after the onset of impaired coordination
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• progressive impaired coordination beginning at 10 to 16 days of age
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• seizures become progressively worse with age
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endocrine/exocrine glands
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• anterior pituitary lobes were congested and hypercellular
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• the cortex appears as a mass of stromal cells and an absence of lymphocytes was noted
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• the thymic medulla is filled with cell debris and pyknotic nuclei
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• thyroid glands appear similar to controls at 11 days of age, but at 33 days of age the colloid is less homogeneous, the secreting cells are abnormally shaped and placed, and the connective tissue displays hyperplasia
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• hypoactive thyroid
• involuted thymus glands; involution is first noted coincident with the onset of impaired coordination
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immune system
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• the cortex appears as a mass of stromal cells and an absence of lymphocytes was noted
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• the thymic medulla is filled with cell debris and pyknotic nuclei
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muscle
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• severe muscle tetany was exhibited after the onset of impaired coordination
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• severe muscle tetany was exhibited after the onset of impaired coordination
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nervous system
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• seizures become progressively worse with age
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• anterior pituitary lobes were congested and hypercellular
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• polycystic alterations in white matter of the brain were noted
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• degeneration of the motor neurons of the lumbar spinal cord was noted; cells appeared vacuolated
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hematopoietic system
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• the cortex appears as a mass of stromal cells and an absence of lymphocytes was noted
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• the thymic medulla is filled with cell debris and pyknotic nuclei
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Analysis Tools