All Phenotypes Scn8a<med-TgA4Bs> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Scn8a^med-TgA4Bs
motor end plate disease (TgA4Bs)
MGI:1856414

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Scn8a^med-TgA4Bs/Scn8a^med-TgA4Bs	B6.Cg-Scn8a^med-TgA4Bs	MGI:3818258
hm2	Scn8a^med-TgA4Bs/Scn8a^med-TgA4Bs	involves: C3H * C57BL/6J	MGI:3818256
ht3	Scn8a^med-TgA4Bs/Scn8a^nur14	involves: C3H * C57BL/6J	MGI:3840663

Allelic Composition	Scn8a^med-TgA4Bs/Scn8a^med-TgA4Bs
Genetic Background	B6.Cg-Scn8a^med-TgA4Bs

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scn8a^med-TgA4Bs mutation (0 available); any Scn8a mutation (99 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal eye electrophysiology ( J:110231 )

• retinal ganglion cells exhibit a subtle but significant decrease in repetitive spikes fired during depolarization compared to in wild-type cells

• retinal ganglion cells firing rates fail to increased between P12 and P18 as in wild-type mice

• retinal ganglion cells are less able to generate spikes at short interspike intervals after depolarization compared to wild-type cells and achieve spike failure sooner than in wild-type cells

Allelic Composition	Scn8a^med-TgA4Bs/Scn8a^med-TgA4Bs
Genetic Background	involves: C3H * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scn8a^med-TgA4Bs mutation (0 available); any Scn8a mutation (99 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:24228 )

• mice die by 25 days of age

behavior/neurological

limb grasping ( J:24228 )

impaired balance ( J:24228 )

• 11 days after birth

hindlimb paralysis ( J:24228 )

• 14 days after birth

muscle

muscular atrophy ( J:24228 )

growth/size/body

decreased body weight ( J:24228 )

nervous system

nervous system phenotype ( J:24228 )

N	• despite abnormal behavior and muscle loss, mice exhibit normal numbers of motor neurons in the spinal cord

Allelic Composition	Scn8a^med-TgA4Bs/Scn8a^nur14
Genetic Background	involves: C3H * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scn8a^med-TgA4Bs mutation (0 available); any Scn8a mutation (99 available)
Scn8a^nur14 mutation (0 available); any Scn8a mutation (99 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality ( J:146758 )

• mice do not survive beyond weaning

behavior/neurological

tremors ( J:146758 )

ataxia ( J:146758 )

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