Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc11a2mk mutation
(2 available);
any
Slc11a2 mutation
(38 available)
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mortality/aging
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N |
• Background Sensitivity: nearly 100% survival to adulthood on a 129S6.Mk/ReJ background
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homeostasis/metabolism
liver/biliary system
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• liver non-heme iron levels higher than in knock-out mice
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Allelic
Composition |
Slc11a2mk/Slc11a2mk
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Genetic
Background |
involves: C57BL/6J * DBA/2J * WB/Re |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc11a2mk mutation
(2 available);
any
Slc11a2 mutation
(38 available)
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hematopoietic system
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• red blood cell protoporphyrin levels are higher than in controls
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homeostasis/metabolism
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc11a2mk mutation
(2 available);
any
Slc11a2 mutation
(38 available)
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cellular
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• homozygous embryos of homozygous mothers have a higher proportion of erythrocytes with pale stain for hemoglobin than do those of heterozygous mothers
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mortality/aging
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• many homozygotes die between 1 and 3 weeks of age
(J:5167)
• Background Sensitivity: only 10% survive to weaning on the MK/ReJ background
(J:98088)
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hematopoietic system
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• mean splenic weight in adults is 206mg versus 88mg in heterozygotes
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• homozygotes can be identified at birth by their pale color due to the small erythrocytes with diminished hemoglobin content, although the red cell counts are not significantly lower than normal
(J:5167)
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• at 6 and 8 weeks of age all homozygotes have considerably increased erythrocyte numbers with low mean cell volumes
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• homozygotes from 10-30 weeks of age have a mean hematocrit of 38.9% while 10-20 week old heterozygous controls have a mean hematocrit of 49.7%
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• severely decreased in adults and as early as embryonic day 15 hemoglobin stain is pale in an abnormally high proportion of erythrocytes
(J:5167)
• Background Sensitivity: hemoglobin concentration in circulating blood ranges from 8.2 to 10.6 g/ml compared with 16.1 to 17.0 in wildtype controls
(J:162917)
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• found as early as embryonic day 15 and persisting into adulthood
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• homozygotes from 10-30 weeks of age have 5.3-28% reticulocytes compared with 10-20 week old heterozygotes with 1.1-5.2% reticulocytes
(J:5167)
• reticulocyte concentration of 15-23% compared with 3-4% in wild-type controls
(J:162917)
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• mean red blood cell lifespan of 24 days compared with 45 days in controls
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homeostasis/metabolism
immune system
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• mean splenic weight in adults is 206mg versus 88mg in heterozygotes
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reproductive system
growth/size/body
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• although normal in weight at birth, by 1 week of age homozygotes have a lower body weight than heterozygous controls and this persists into adulhood
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• mean splenic weight in adults is 206mg versus 88mg in heterozygotes
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liver/biliary system
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N |
• no evidence of jaundice
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integument
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• homozygotes can develop skin lesions in the postnatal period
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc11a2mk mutation
(2 available);
any
Slc11a2 mutation
(38 available)
|
|
|
mortality/aging
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• many homozygotes die between 1 and 3 weeks of age
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cellular
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• homozygous embryos of homozygous mothers have a higher proportion of erythrocytes with pale stain for hemoglobin than do those of heterozygous mothers
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hematopoietic system
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• homozygotes can be identified at birth by their pale color due to the small erythrocytes with diminished hemoglobin content, although the red cell counts are not significantly lower than normal
(J:5167)
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• at 6 and 8 weeks of age all homozygotes have considerably increased erythrocyte numbers with low mean cell volumes
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• at 8 weeks of age females have a mean hematocrit of 38.9% compared with 48.5% in heterozygous controls and males have a mean hematocrit of 40.3% compared with 50% in heterozygous controls
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• decreased in females from 17.1g in heterozygous controls to 20.6g per 100 cc blood and in males from 17.8g in heterozygous controls to 11.2g per 100cc blood
(J:5167)
• as early as embryonic day 15 hemoglobin stain is pale in an abnormally high proportion of erythrocytes
(J:5167)
• Background Sensitivity: hemoglobin concentration in circulating blood ranges from 6.1 to 7.8 g/ml compared with 16.1 to 17.0 in wildtype controls
(J:162917)
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• decreased from 17.4g to 8g per 100cc packed red cells in females and from 16.3g to 8g per 100cc packed red cells in males
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• found as early as embryonic day 15 and persisting into adulthood
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• reticulocyte concentration of 15-23% compared with 3-4% in wild-type controls
(J:162917)
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• Background Sensitivity: mean red blood cell lifespan of 15 days compared with 45 days in controls, with splenectomy increasing red blood cell lifespan to 23 days
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• the red blood cell population contains a smaller population of osmotically sensitive cells and a larger population of osmotically resistant cells
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growth/size/body
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• although normal in weight at birth, by 1 week of age homozygotes have a lower body weight than heterozygous controls and this persists into adulhood
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immune system
reproductive system
liver/biliary system
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N |
• no evidence of jaundice
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integument
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• homozygotes can develop skin lesions in the postnatal period
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mortality/aging
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• some mice die prior to weaning
• increased viability relative to Slc11a2mk homozygous mutant mice
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homeostasis/metabolism
liver/biliary system
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• hepatic iron levels similar to those observed in Slc11a2mk homozygous mutant mice
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Analysis Tools
