All Phenotypes Gnrh1<hpg> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gnrh1^hpg/Gnrh1^hpg	HPG/BmJ	MGI:3807534
hm2	Gnrh1^hpg/Gnrh1^hpg	involves: 101/H * C3H/HeH	MGI:2663794
cx3	Prkdc^scid/Prkdc^scid Gnrh1^hpg/Gnrh1^hpg	STOCK Prkdc^scid Gnrh1^hpg/Bm	MGI:3581148
cx4	Gnrh1^hpg/Gnrh1^hpg Inha^tm1Bay/Inha^tm1Bay	involves: 129S7/SvEvBrd * C57BL/6 * HPG/Bm	MGI:2662292

Allelic Composition	Gnrh1^hpg/Gnrh1^hpg
Genetic Background	HPG/BmJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnrh1^hpg mutation (2 available); any Gnrh1 mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Characterization of Gnrh1^hpg/Gnrh1^hpg mice

hematopoietic system

increased bone marrow cell number ( J:19436 )

• Background Sensitivity: bone marrow has a modest increase in total nucleated cells, accounted for by increases in B lineage lymphocytes

increased B cell number ( J:19436 )

• Background Sensitivity: bone marrow and spleen have significantly more B cells, both immature and mature, than normal, and increasing serum estrogen decreases the number of B cells

increased immature B cell number ( J:19436 )

• Background Sensitivity: in bone marrow and spleen

increased mature B cell number ( J:19436 )

• Background Sensitivity: in bone marrow and spleen

abnormal splenic cell ratio ( J:19436 )

• Background Sensitivity: splenic B cell population is approximately 2 fold higher than normal although no change is found in the number of Mac1 positive splenocytes

immune system

increased B cell number ( J:19436 )

• Background Sensitivity: bone marrow and spleen have significantly more B cells, both immature and mature, than normal, and increasing serum estrogen decreases the number of B cells

increased immature B cell number ( J:19436 )

• Background Sensitivity: in bone marrow and spleen

increased mature B cell number ( J:19436 )

• Background Sensitivity: in bone marrow and spleen

abnormal splenic cell ratio ( J:19436 )

• Background Sensitivity: splenic B cell population is approximately 2 fold higher than normal although no change is found in the number of Mac1 positive splenocytes

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal anogenital distance ( J:5877 )

• males exhbited a reduced distance

abnormal sex gland morphology ( J:5877 )

small seminal vesicle ( J:5877 )

• arrested development

impaired ovarian folliculogenesis ( J:5877 )

• though some follicles were observed in the early stages of antrum formation, most were arrested at the pre-antral phase

small ovary ( J:5877 )

• arrested development

absent Leydig cells ( J:157337 )

small testis ( J:5877 )

• arrested development

cryptorchism ( J:5877 )

• testes located in the abdomen

abnormal female reproductive system morphology ( J:5877 )

small uterus ( J:5877 )

• arrested development

abnormal vagina orifice morphology ( J:5877 )

• failure of vagina to open fully

abnormal gametogenesis ( J:5877 )

arrest of male meiosis ( J:5877 )

• rarely advanced beyond the diplotene stage

abnormal male reproductive system morphology ( J:5877 )

small penis ( J:5877 )

abnormal scrotum morphology ( J:5877 )

• underdeveloped scrotum

endocrine/exocrine glands

abnormal sex gland morphology ( J:5877 )

small seminal vesicle ( J:5877 )

• arrested development

impaired ovarian folliculogenesis ( J:5877 )

• though some follicles were observed in the early stages of antrum formation, most were arrested at the pre-antral phase

small ovary ( J:5877 )

• arrested development

absent Leydig cells ( J:157337 )

small testis ( J:5877 )

• arrested development

cryptorchism ( J:5877 )

• testes located in the abdomen

abnormal pituitary gland physiology ( J:5877 )

growth/size/body

decreased body weight ( J:5877 )

• male specific decrease in body weight evident at 6 weeks of age, putatively due to testosterone deficiency

nervous system

nervous system phenotype ( J:5877 )

N	• no abnormalities found

abnormal pituitary gland physiology ( J:5877 )

skeleton

skeleton phenotype ( J:5877 )

N	• no craniofacial abnormalities

homeostasis/metabolism

decreased adrenocorticotropin level ( J:5877 )

• reduced levels in the pituitary in both males and females

decreased follicle stimulating hormone level ( J:5877 )

• reduced levels in the pituitary in both males and females

decreased circulating follicle stimulating hormone level ( J:5877 )

• reduced levels in both males and females

decreased luteinizing hormone level ( J:5877 )

• reduced levels in the pituitary in both males and females

decreased prolactin level ( J:5877 )

• reduced levels in the pituitary in both males and females

renal/urinary system

small penis ( J:5877 )

digestive/alimentary system

abnormal anogenital distance ( J:5877 )

• males exhbited a reduced distance

integument

thin skin ( J:5877 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hypogonadotropic hypogonadism 12 with or without anosmia		DOID:0090072	OMIM:614841	J:5877

Allelic Composition	Prkdc^scid/Prkdc^scid Gnrh1^hpg/Gnrh1^hpg
Genetic Background	STOCK Prkdc^scid Gnrh1^hpg/Bm

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnrh1^hpg mutation (2 available); any Gnrh1 mutation (10 available)
Prkdc^scid mutation (171 available); any Prkdc mutation (408 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased tumor incidence ( J:14443 , J:138840 )

• ovaries grafted from (SWR x SWXJ-9)F1, which are prone to granulosa cell tumor generation, do not form granulosa cell tumors in these hypogonadal immunodeficient hosts (J:14443)

• implanted human prostate adenocarcinoma tissue assessed 3 weeks after transplantation shows two histologic patterns, undifferentiated tumors and tumors that are more differentiated but have few glandular structures, and are smaller and histologically different from the tumors from the same donor transplanted into androgen repleted immunodeficiant hosts (J:138840)

homeostasis/metabolism

decreased circulating testosterone level ( J:138840 )

• no detectable serum testosterone

abnormal circulating protein level ( J:138840 )

• serum lacks detectable prostate-specific antigen

digestive/alimentary system

small salivary gland ( J:138840 )

endocrine/exocrine glands

small salivary gland ( J:138840 )

absent seminal vesicle ( J:138840 )

liver/biliary system

decreased liver weight ( J:138840 )

renal/urinary system

decreased kidney weight ( J:138840 )

reproductive system

absent seminal vesicle ( J:138840 )

Allelic Composition	Gnrh1^hpg/Gnrh1^hpg Inha^tm1Bay/Inha^tm1Bay
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6 * HPG/Bm

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnrh1^hpg mutation (2 available); any Gnrh1 mutation (10 available)
Inha^tm1Bay mutation (0 available); any Inha mutation (9 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:83261 )

• mice survive past 1 year of age, do not exhibit cachexia, and do not develop either gonadal or adrenal tumors

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