Phenotypes associated with this allele

• Allele Symbol: Gdf5^bp-3J
• Allele Name: brachypodism 3 Jackson
• Allele ID: MGI:1856340
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gdf5^bp-3J/Gdf5^bp-3J	involves: BALB/cJ	MGI:2168885

Genotype
MGI:2168885

hm1

• Allelic Composition: Gdf5^bp-3J/Gdf5^bp-3J
• Genetic Background: involves: BALB/cJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

abnormal limb mesenchyme morphology ( J:17582 )

• mesenchyme from mutant mice shows a reduced ability to form aggregates and cartilaginous nodules in vitro

limbs/digits/tail

abnormal limb mesenchyme morphology ( J:17582 )

• mesenchyme from mutant mice shows a reduced ability to form aggregates and cartilaginous nodules in vitro

brachypodia ( J:17582 )

• feet are much shorter than controls

abnormal carpal bone morphology ( J:17582 , J:38423 )

• slight disorganization of the carpals and tarsals (J:17582)

• the majority of mice display partial or complete fusion of the wrist and a combination of carpal bones including capitate/hamate bone fusions, centrale/capitate/hamate bone fusions, and/or fusion of trapezoid/centrale and capitate/hamate bones (J:38423)

fused carpal bones ( J:38423 )

abnormal digit morphology ( J:17582 , J:38423 )

• the reduction in length of the feet is largely the result of altered patterning of segments in the digits (J:17582)

abnormal phalanx morphology ( J:38423 )

fused phalanges ( J:17582 )

• in place of the proximal and medial phalanges is a single bone resulting from a fusion of the proximal and medial phalangeal condensations

abnormal tarsal bone morphology ( J:17582 , J:38423 )

• slight disorganization of the carpals and tarsals (J:17582)

• partial or complete fusion of tarsals (navicular/lateral/cuneiform) (J:38423)

• partial or complete fusion of proximal/medial phalanges, digits II-V (J:38423)

abnormal patella morphology ( J:38423 )

• medial displacement

• failed mineralization of menisci

abnormal metacarpal bone morphology ( J:38423 )

• 1 of 2 metacarpo-phalangeal sesamoids of digit II may be absent or reduced in size

• there is partial or complete fusion of the metacarpal/proximal phalanx of digit V, proximal/medial phalanges of digits II-V, and metacarpo-phalangeal sesamoids of digits III and IV

short metacarpal bones ( J:17582 )

• defects in the length of the metacarpals

abnormal metatarsal bone morphology ( J:38423 )

• growth plates of digits II and V are absent or reduced in size

short metatarsal bones ( J:17582 )

• defects in the length of the metatarsals

abnormal digit development ( J:17582 )

• digit condensations in mutant mice are thin, malformed, and slow to initiate chondrogenesis

skeleton

abnormal carpal bone morphology ( J:17582 , J:38423 )

• slight disorganization of the carpals and tarsals (J:17582)

• the majority of mice display partial or complete fusion of the wrist and a combination of carpal bones including capitate/hamate bone fusions, centrale/capitate/hamate bone fusions, and/or fusion of trapezoid/centrale and capitate/hamate bones (J:38423)

fused carpal bones ( J:38423 )

abnormal phalanx morphology ( J:38423 )

fused phalanges ( J:17582 )

• in place of the proximal and medial phalanges is a single bone resulting from a fusion of the proximal and medial phalangeal condensations

abnormal tarsal bone morphology ( J:17582 , J:38423 )

• slight disorganization of the carpals and tarsals (J:17582)

• partial or complete fusion of tarsals (navicular/lateral/cuneiform) (J:38423)

• partial or complete fusion of proximal/medial phalanges, digits II-V (J:38423)

abnormal patella morphology ( J:38423 )

• medial displacement

• failed mineralization of menisci

abnormal metacarpal bone morphology ( J:38423 )

• 1 of 2 metacarpo-phalangeal sesamoids of digit II may be absent or reduced in size

• there is partial or complete fusion of the metacarpal/proximal phalanx of digit V, proximal/medial phalanges of digits II-V, and metacarpo-phalangeal sesamoids of digits III and IV

abnormal metatarsal bone morphology ( J:38423 )

• growth plates of digits II and V are absent or reduced in size

decreased length of long bones ( J:17582 )

• long bones of the limb are slightly shorter

short metacarpal bones ( J:17582 )

• defects in the length of the metacarpals

short metatarsal bones ( J:17582 )

• defects in the length of the metatarsals