Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmdmdx-2Cv mutation
(1 available);
any
Dmd mutation
(153 available)
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muscle
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• mice exhibit fibrosis, fatty infiltration and necrosis in the diaphragm unlike in wild-type mice that increases with age
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• mice exhibit progressive fibrosis of the diaphragm with age, unlike in wild-type mice
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmdmdx-2Cv mutation
(1 available);
any
Dmd mutation
(153 available)
|
|
|
muscle
|
• mice exhibit fibrosis, fatty infiltration and necrosis in the diaphragm unlike in wild-type mice that increases with age
|
|
• mice exhibit progressive fibrosis of the diaphragm with age, unlike in wild-type mice
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmdmdx-2Cv mutation
(1 available);
any
Dmd mutation
(153 available)
|
|
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vision/eye
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• derived positive (P2) responses are delayed compared to in wild-type mice
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Allelic Composition |
Dmdmdx-2Cv/Y
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Genetic Background |
involves: C3H/HeHa * C57BL/6Ros * C57BL/10Sn * M. m. castaneus * M. m. musculus |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmdmdx-2Cv mutation
(1 available);
any
Dmd mutation
(153 available)
|
|
|
muscle
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• mice exhibit skeletal muscle fiber degeneration, regeneration and sometimes fibrosis
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• mice exhibit skeletal muscle fiber degeneration, regeneration and sometimes fibrosis
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• electromyograms reveal peudomyotonia unlike in wild-type mice
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cardiovascular system
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• unlike wild-type, minimal to focal cardiac fibrosis is observed
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