All Phenotypes Tyr<c-25H> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tyr^c-25H
albino 25 Harwell
MGI:1856306

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tyr^c-25H/Tyr^c-25H	involves: 101/H * AKR * C3H/H	MGI:3663886
ht2	Tyr^c-25H/Tyr⁺	involves: AKR * STOCK Tyr^c-25H/Tyr^c-ch	MGI:3691584
ht3	Tyr^c-25H/Tyr⁺	involves: SM/J * STOCK Tyr^c-h/Tyr^c-25H	MGI:3691849
ht4	Tyr^c-h/Tyr^c-25H	STOCK Tyr^c-h/Tyr^c-25H	MGI:3691858

Allelic Composition	Tyr^c-25H/Tyr^c-25H
Genetic Background	involves: 101/H * AKR * C3H/H

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyr^c-25H mutation (0 available); any Tyr mutation (375 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality before implantation, complete penetrance ( J:6256 )

cellular

abnormal cell morphology ( J:6256 )

abnormal cell nucleus morphology ( J:6256 )

• an ultrastructural study shows nuclei of embryonic cells are abnormally shaped

embryo

failure of zygotic cell division ( J:6256 )

• development is arrested at the 2-to 6-cell stages

• developmental arrest is observed when normal embryos are in early morula or blastocyst stages

Allelic Composition	Tyr^c-25H/Tyr⁺
Genetic Background	involves: AKR * STOCK Tyr^c-25H/Tyr^c-ch

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyr^c-25H mutation (0 available); any Tyr mutation (375 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal chromosome morphology ( J:5520 )

• this allele includes a deletion, detected in banded mitotic chromosomes, comprising 1-6cM, representing about 7.6% of Chr 7

induced chromosome breakage ( J:5520 )

Allelic Composition	Tyr^c-25H/Tyr⁺
Genetic Background	involves: SM/J * STOCK Tyr^c-h/Tyr^c-25H

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyr^c-25H mutation (0 available); any Tyr mutation (375 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

chromosome breakage ( J:5437 )

induced chromosome breakage ( J:5437 )

• an induced, associated deletion involves, minimally, the MOD2 structural locus

Allelic Composition	Tyr^c-h/Tyr^c-25H
Genetic Background	STOCK Tyr^c-h/Tyr^c-25H

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyr^c-25H mutation (0 available); any Tyr mutation (375 available)
Tyr^c-h mutation (2 available); any Tyr mutation (375 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:5437 )

diluted coat color ( J:5437 )

• coat color is lighter than homozygous chinchilla but not albino

integument

abnormal coat/hair pigmentation ( J:5437 )

diluted coat color ( J:5437 )

• coat color is lighter than homozygous chinchilla but not albino

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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