Phenotypes associated with this allele

• Allele Symbol: Pax3^Sp-2J
• Allele Name: splotch 2 Jackson
• Allele ID: MGI:1856296
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pax3^Sp-2J/Pax3^Sp-2J	either: C3H/HeJ-Pax3^Sp-2J or (involves: C3H/HeJ * C57BL/6J)	MGI:5763616
ht2	Pax3^Sp-2J/Pax3^+	C3H/HeJ-Pax3^Sp-2J	MGI:3713856
ht3	Pax3^Sp-2J/Pax3^+	involves: C3H/HeJ * C57BL/6J	MGI:5763614

Genotype
MGI:5763616

hm1

• Allelic Composition: Pax3^Sp-2J/Pax3^Sp-2J
• Genetic Background: either: C3H/HeJ-Pax3^Sp-2J or (involves: C3H/HeJ * C57BL/6J)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:238 )

• matings between heterozygous mutants yielded mutant (belly spot with or without head blaze) and wild-type pups in a 2:1 ratio (89:44).

• examination at various gestational time points revealed resorption of ~13.8% of embryos and abnormal development of 26.4% of those alive when examined

Genotype
MGI:3713856

ht2

• Allelic Composition: Pax3^Sp-2J/Pax3⁺
• Genetic Background: C3H/HeJ-Pax3^Sp-2J

pigmentation

belly spot ( J:238 )

• large belly spot

head spot ( J:238 )

• Background Sensitivity: a head blaze is usually present in addition to the belly spot on the C3H/HeJ background; occasionally the head blaze is absent.

integument

belly spot ( J:238 )

• large belly spot

head spot ( J:238 )

• Background Sensitivity: a head blaze is usually present in addition to the belly spot on the C3H/HeJ background; occasionally the head blaze is absent.

Genotype
MGI:5763614

ht3

• Allelic Composition: Pax3^Sp-2J/Pax3⁺
• Genetic Background: involves: C3H/HeJ * C57BL/6J

integument

belly spot ( J:238 )

• a large belly spot is observed when this mutation is outcrossed to C57BL/6J.

• Background Sensitivity: the head blaze observed in mutant mice on the C3H/HeJ background is not present in the mixed background.

pigmentation

belly spot ( J:238 )

• a large belly spot is observed when this mutation is outcrossed to C57BL/6J.

• Background Sensitivity: the head blaze observed in mutant mice on the C3H/HeJ background is not present in the mixed background.