All Phenotypes Kit<W-37J> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Kit^W-37J
dominant spotting 37 Jackson
MGI:1856241

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kit^W-37J/Kit^W-37J	C57BL/6J-Kit^W-37J/J	MGI:3813672
ht2	Kit^W-37J/Kit⁺	C57BL/6J-Kit^W-37J/J	MGI:3813673
ht3	Kit^W-37J/Kit⁺	involves: C57BL/6 * C57BL/6J	MGI:3813820
ht4	Kit^W-37J/Kit^W	involves: C57BL/6 * C57BL/6J * WB	MGI:3813819
ht5	Kit^W-37J/Kit^W-39J	involves: C57BL/6J	MGI:3813689

Allelic Composition	Kit^W-37J/Kit^W-37J
Genetic Background	C57BL/6J-Kit^W-37J/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kit^W-37J mutation (2 available); any Kit mutation (179 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:6571 )

• mice die in mid-gestation or immediately after birth

prenatal lethality, incomplete penetrance ( J:6571 )

• mice die in mid-gestation or immediately after birth

Allelic Composition	Kit^W-37J/Kit⁺
Genetic Background	C57BL/6J-Kit^W-37J/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kit^W-37J mutation (2 available); any Kit mutation (179 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

polycythemia ( J:6571 )

• borderline

pigmentation

irregular coat pigmentation ( J:6571 )

• some mice exhibit mosaic coat patterns

white spotting ( J:6571 )

• 85% of the coat is white with flecks of pigmented hair on the head, around the eyes, at the base of the ears and on the rump

integument

irregular coat pigmentation ( J:6571 )

• some mice exhibit mosaic coat patterns

white spotting ( J:6571 )

• 85% of the coat is white with flecks of pigmented hair on the head, around the eyes, at the base of the ears and on the rump

Allelic Composition	Kit^W-37J/Kit⁺
Genetic Background	involves: C57BL/6 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kit^W-37J mutation (2 available); any Kit mutation (179 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased mast cell number ( J:27513 )

• mice exhibit slightly fewer mast cells in the skin than wild-type mice

hematopoietic system

decreased mast cell number ( J:27513 )

• mice exhibit slightly fewer mast cells in the skin than wild-type mice

pigmentation

diluted coat color ( J:27513 )

• slightly

white spotting ( J:27513 )

integument

diluted coat color ( J:27513 )

• slightly

white spotting ( J:27513 )

Allelic Composition	Kit^W-37J/Kit^W
Genetic Background	involves: C57BL/6 * C57BL/6J * WB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kit^W mutation (10 available); any Kit mutation (179 available)
Kit^W-37J mutation (2 available); any Kit mutation (179 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased mast cell number ( J:27513 )

• mice exhibit no mast cells in the skin

abnormal mast cell physiology ( J:27513 )

• mast cells do not survive co-culture with fibroblast cells and exhibit impaired attachment

hematopoietic system

decreased mast cell number ( J:27513 )

• mice exhibit no mast cells in the skin

abnormal mast cell physiology ( J:27513 )

• mast cells do not survive co-culture with fibroblast cells and exhibit impaired attachment

pigmentation

absent coat pigmentation ( J:27513 )

• mice are black-eyed with white coats

integument

absent coat pigmentation ( J:27513 )

• mice are black-eyed with white coats

Allelic Composition	Kit^W-37J/Kit^W-39J
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kit^W-37J mutation (2 available); any Kit mutation (179 available)
Kit^W-39J mutation (2 available); any Kit mutation (179 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:6571 )

• fewer than expected mice are born alive

reproductive system

abnormal ovarian follicle number ( J:6571 )

• ovaries contain fewer developing follicles than in wild-type mice

small ovary ( J:6571 )

small testis ( J:6571 )

abnormal spermatogenesis ( J:6571 )

• mice lack spermatogenic activity

infertility ( J:6571 )

endocrine/exocrine glands

abnormal ovarian follicle number ( J:6571 )

• ovaries contain fewer developing follicles than in wild-type mice

small ovary ( J:6571 )

small testis ( J:6571 )

pigmentation

absent coat pigmentation ( J:6571 )

• mice are black-eyed with white coats

integument

absent coat pigmentation ( J:6571 )

• mice are black-eyed with white coats

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