Phenotypes associated with this allele

• Allele Symbol: Cdh23^v-df
• Allele Name: deaf
• Allele ID: MGI:1856229
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cdh23^v-df/Cdh23^v-df	Not Specified	MGI:5634728

Genotype
MGI:5634728

hm1

• Allelic Composition: Cdh23^v-df/Cdh23^v-df
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hearing/vestibular/ear

abnormal ear position ( J:12997 )

organ of Corti degeneration ( J:12997 )

• earliest signs of degeneration, shortened hair-cells and downward movement of nuclei of Deiter's cells, are seen in histological analyses when mutant mice are 17 days of age

• Background Sensitivity: shortening of hair-cells continues from 26-86 days

• only the rods of Corti remain unaffected

abnormal stria vascularis morphology ( J:12997 )

deafness ( J:12997 )

• Background Sensitivity: most mutant mice show early deafness, between 13 and 15 days of age, but individuals may hear much longer

• Background Sensitivity: mice homozygous for Cdh23^v-df and Myo7a^sh1 maintain the ability to hear longer than mice homozygous for Cdh23^v-df

growth/size/body

abnormal ear position ( J:12997 )

craniofacial

abnormal ear position ( J:12997 )

behavior/neurological

abnormal motor capabilities/coordination/movement ( J:12997 )

• only hearing is affected; coordination and swimming ability are normal

absent pinna reflex ( J:12997 )

nervous system

abnormal cochlear ganglion morphology ( J:12997 )

• Background Sensitivity: evident by 26 days of age with most of the decine in hearing occurring in young mice