Phenotypes associated with this allele
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pmp22Tr mutation
(0 available);
any
Pmp22 mutation
(32 available)
|
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mortality/aging
N |
• mice have normal a lifespan
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nervous system
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• Shwann cells attach to axons but fail to form myelin
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• axons are virtually devoid of myelin
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behavior/neurological
Allelic Composition |
Pmp22Tr/Pmp22+
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Genetic Background |
Not Specified |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pmp22Tr mutation
(0 available);
any
Pmp22 mutation
(32 available)
|
|
|
mortality/aging
N |
• mice have normal a lifespan
|
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• majority die soon after 3 weeks of age unless they are provided with easily accessible moist food
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behavior/neurological
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• adults exhibit trembling consisting of a very rapid side to side movement of the head and neck
(J:13038)
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• exhibit difficulty walking and appear to totter along on the tips of toes
(J:13038)
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• young mutants (by 3 weeks of age) exhibit spastic paralysis affecting both pairs of legs that persists into adult life but is less severe than at young age
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• young mutants (by 3 weeks of age) exhibit spastic paralysis affecting both pairs of legs that persists into adult life but is less severe than at young age
• paralysis is more conspicuous in the hind legs, which are held out stiffly behind or to the sides
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• young mutants (by 3 weeks of age) exhibit convulsions in response to stimulation
• convulsions are not normally seen in adults but can be induced by a strong stimulus
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nervous system
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• young mutants (by 3 weeks of age) exhibit convulsions in response to stimulation
• convulsions are not normally seen in adults but can be induced by a strong stimulus
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• Shwann cells attach to axons but fail to form myelin
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• axons only have a thin layer of myelination
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reproductive system
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• males are frequently sterile and those that breed do so irregularly
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growth/size/body
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• smaller at 3 weeks of age
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Allelic Composition |
Pmp22Tr/?
|
|
Genetic Background |
involves: CBA |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pmp22Tr mutation
(0 available);
any
Pmp22 mutation
(32 available)
|
|
|
nervous system
|
• Schwann cell density is increased from P4 onwards compared to in wild-type mice
• at P10 and 10 weeks of age, Schwann cell proliferation is increased compared to in wild-type mice
• at P21 and 10 weeks of age, mice exhibit increased Schwann cell apoptosis compared to in wild-type mice
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Allelic Composition |
Pmp22Tr/?
|
|
Genetic Background |
Not Specified |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pmp22Tr mutation
(0 available);
any
Pmp22 mutation
(32 available)
|
|
|
nervous system
behavior/neurological