Phenotypes associated with this allele
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Glra1spd-ot mutation
(1 available);
any
Glra1 mutation
(30 available)
|
|
|
mortality/aging
|
|
• usually die about 22-23 days of age
|
behavior/neurological
|
|
• begin to tremble violently and very rapidly at about 14 days of age; severity of tremor increases daily
• at 19-21 days of age, mutants have prolonged periods of great rigor or stiffness; therapy with aminooxyacetic acid is helpful but only temporarily
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Glra1spd-ot mutation
(1 available);
any
Glra1 mutation
(30 available)
|
|
|
mortality/aging
|
|
• homozygotes die by the end of the third week after birth
|
nervous system
|
N |
• mice exhibit normal spontaenous glycinergic inhibitory postsynaptic currents in amacrine cells
|
|
|
• in mutants there is a reduction or absence of post-inspiratory neurons compared to wild-type
|
|
|
• phrenic nerve discharge patterns of mutant mice vary with respect to burst frequency and duration of expiration and inspiration compared to wild-type mice; mutants displayed more frequent phrenic nerve discharges with shorter, less regular expiratory intervals
|
muscle
|
|
• after rapid breathing episodes, single or multiple whole-body spasms occur with intervals between spasms of 6 seconds to more than 1 minute
|
respiratory system
|
|
• conscious mutants (P16-23) display disturbed respiratory patterns characterized by periods of slow breathing and intermittent episodes of rapid breathing; episodes are of variable (2-10 sec)
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Glra1m1Cpai mutation
(0 available);
any
Glra1 mutation
(30 available)
Glra1spd-ot mutation
(1 available);
any
Glra1 mutation
(30 available)
|
|
|
mortality/aging
|
|
• mice die 4 weeks after birth
|
Analysis Tools