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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sptbn4qv
quivering
MGI:1856132
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Sptbn4qv/Sptbn4qv either: (involves: BALB/c) or (involves: C57BL/10) MGI:5617031
hm2
 		Sptbn4qv/Sptbn4qv involves: CBA/Gr MGI:3720870
hm3
 		Sptbn4qv/Sptbn4qv Not Specified MGI:5617054


Genotype
MGI:5617031
hm1
Allelic
Composition		 Sptbn4qv/Sptbn4qv
Genetic
Background		 either: (involves: BALB/c) or (involves: C57BL/10)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sptbn4qv mutation (0 available); any Sptbn4 mutation (121 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
tremors ( J:167 )
• quivering becomes pronounced as mice age
ataxia ( J:167 )
• evident as early as 14 days of age
paralysis ( J:167 )
• from 30 days of age mice show hindlimb and tail stiffening in varying degrees
hindlimb paralysis ( J:167 )
• observed from 30 days of age

reproductive system
priapism ( J:167 )
• occurs in the majority of males several days before death
male infertility ( J:167 )
• males have viable sperm but do not sire litters
• posterior paralysis precludes normal copulation behavior

hearing/vestibular/ear

immune system
eye inflammation ( J:167 )
• mice may develop eye infections

vision/eye
eye inflammation ( J:167 )
• mice may develop eye infections

mortality/aging
premature death ( J:167 )
• the majority of mice die before 5 months of age




Genotype
MGI:3720870
hm2
Allelic
Composition		 Sptbn4qv/Sptbn4qv
Genetic
Background		 involves: CBA/Gr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sptbn4qv mutation (0 available); any Sptbn4 mutation (121 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
abnormal auditory brainstem response ( J:71549 )
• the initial ABR peak, which corresponds to the compound action potential of the eighth cranial nerve, is broadened and delayed and a second vaveform peak is sometimes present




Genotype
MGI:5617054
hm3
Allelic
Composition		 Sptbn4qv/Sptbn4qv
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sptbn4qv mutation (0 available); any Sptbn4 mutation (121 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
deafness ( J:32693 )
• by experimantal elimination, deafness is due to a central auditory dysfunction associated with the superior olivary complex and lateral lemniscus




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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory