Phenotypes associated with this allele

• Allele Symbol: Oca2^p-un
• Allele Name: pink-eyed dilution unstable
• Allele ID: MGI:1856123
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Oca2^p-un/Oca2^p-un	C57BL/6J-Oca2^p-un	MGI:3693298
ht2	Oca2^p-un/Oca2^p-un+J	C57BL/6J-Oca2^p-un	MGI:3700647

Genotype
MGI:3693298

hm1

• Allelic Composition: Oca2^p-un/Oca2^p-un
• Genetic Background: C57BL/6J-Oca2^p-un

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:85780 )

diluted coat color ( J:85780 )

• mice appear gray on this non-agouti black background

mosaic coat color ( J:85780 )

• extent varies from a few isolated black hairs to heavily mottled

• areas of wild-type, black, coat color, carry somatic revertant mutations to Oca2⁺

mottled coat ( J:5226 , J:11138 )

• coats of 1.8% of offspring of homozygous parents are gray/black mottled (J:5226)

• mottling indicates reversion to wild-type coat color which occurs 3-5 times more frequent than for other p alleles or recessive muations at other coat color loci (J:11138)

• revertant lines can be established from inter se matings of mottled mice or matings of homozygous pink-unstabe mice to mottled mice (J:11138)

abnormal eye pigmentation ( J:85780 )

• mice with mosaic coats have eye pigmentation ranging from pink-eyed to mosaic to black

• eye pigmentation is often bilaterally asymmetrical

vision/eye

abnormal eye pigmentation ( J:85780 )

• mice with mosaic coats have eye pigmentation ranging from pink-eyed to mosaic to black

• eye pigmentation is often bilaterally asymmetrical

integument

abnormal coat/hair pigmentation ( J:85780 )

diluted coat color ( J:85780 )

• mice appear gray on this non-agouti black background

mosaic coat color ( J:85780 )

• extent varies from a few isolated black hairs to heavily mottled

• areas of wild-type, black, coat color, carry somatic revertant mutations to Oca2⁺

mottled coat ( J:5226 , J:11138 )

• coats of 1.8% of offspring of homozygous parents are gray/black mottled (J:5226)

• mottling indicates reversion to wild-type coat color which occurs 3-5 times more frequent than for other p alleles or recessive muations at other coat color loci (J:11138)

• revertant lines can be established from inter se matings of mottled mice or matings of homozygous pink-unstabe mice to mottled mice (J:11138)

Genotype
MGI:3700647

ht2

• Allelic Composition: Oca2^p-un/Oca2^p-un+J
• Genetic Background: C57BL/6J-Oca2^p-un

normal phenotype

phenotypic reversion ( J:11138 )

• the initial reversion event is random resulting in a mouse mosaic for mutant gray and revertant wild-type black pigmentation; this mouse can be bred to produce offspring with an entirely wild-type, non-agouti black coat

• the initial reversion event is random resulting in a mouse mosaic for reduced eye pigmentation and revertant wild-type black pigmentation; this mouse can be bred to produce offspring with an entirely wild-type, black eyes

pigmentation

variegated coat color ( J:11138 )

• the initial revertion event is random resulting in a mouse mosaic for mutant gray and revertant wild-type black pigmentation; this mouse can be bred to produce offspring with an entirely wild-type, non-agouti black coat

abnormal eye pigmentation ( J:11138 )

• the initial revertion event is random resulting in a mouse mosaic for reduced eye pigmentation and revertant wild-type black pigmentation; this mouse can be bred to produce offspring with an entirely wild-type, black eyes

decreased eye pigmentation ( J:11138 )

• the initial revertion event is random resulting in a mouse mosaic for reduced eye pigmentation and revertant wild-type black pigmentation; this mouse can be bred to produce offspring with an entirely wild-type, black eyes

vision/eye

abnormal eye pigmentation ( J:11138 )

• the initial revertion event is random resulting in a mouse mosaic for reduced eye pigmentation and revertant wild-type black pigmentation; this mouse can be bred to produce offspring with an entirely wild-type, black eyes

decreased eye pigmentation ( J:11138 )

• the initial revertion event is random resulting in a mouse mosaic for reduced eye pigmentation and revertant wild-type black pigmentation; this mouse can be bred to produce offspring with an entirely wild-type, black eyes

integument

variegated coat color ( J:11138 )

• the initial revertion event is random resulting in a mouse mosaic for mutant gray and revertant wild-type black pigmentation; this mouse can be bred to produce offspring with an entirely wild-type, non-agouti black coat