All Phenotypes Atp7a<Mo-brJ> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Atp7a^Mo-brJ
mottled brindled Jackson
MGI:1856103

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Atp7a^Mo-brJ/Atp7a⁺	involves: C3H/HeJ * C57BL/6J	MGI:4361580
cx2	Atp7a^Mo-brJ/Atp7a⁺ Mt1^tm1Bri/Mt1^tm1Bri Mt2^tm1Bri/Mt2^tm1Bri	involves: 129S7/SvEvBrd * C3H/HeJ	MGI:4361578
cx3	Atp7a^Mo-brJ/Atp7a⁺ Mt1^tm1Bri/Mt1^tm1Bri Mt2^tm1Bri/Mt2^tm1Bri Tg(Mt1)174Bri/0	involves: 129S7/SvEvBrd * C3H/HeJ * C57BL/6 * SJL	MGI:4361575
cx4	Atp7a^Mo-brJ/Y Mt1^tm1Bri/Mt1^tm1Bri Mt2^tm1Bri/Mt2^tm1Bri	involves: 129S7/SvEvBrd * C3H/HeJ * C57BL/6J	MGI:4361577
ot5	Atp7a^Mo-brJ/Y	involves: C3H/HeJ * C57BL/6J	MGI:4361579

Allelic Composition	Atp7a^Mo-brJ/Atp7a⁺
Genetic Background	involves: C3H/HeJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp7a^Mo-brJ mutation (0 available); any Atp7a mutation (69 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:33276 )

N	• mice exhibit normal copper levels

Allelic Composition	Atp7a^Mo-brJ/Atp7a⁺ Mt1^tm1Bri/Mt1^tm1Bri Mt2^tm1Bri/Mt2^tm1Bri
Genetic Background	involves: 129S7/SvEvBrd * C3H/HeJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp7a^Mo-brJ mutation (0 available); any Atp7a mutation (69 available)
Mt1^tm1Bri mutation (1 available); any Mt1 mutation (49 available)
Mt2^tm1Bri mutation (1 available); any Mt2 mutation (8 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:33276 )

• no mice are recovered at E11

cellular

increased sensitivity to induced cell death ( J:33276 )

• cells from E11 embryos exhibit increased cell death when cultured with copper compared with similarly treated heterozygous cells

growth/size/body

decreased body size ( J:33276 )

• the one surviving mouse was runted

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:33276 )

N	• the one recovered mouse had normal copper levels in the intestine and liver

Allelic Composition	Atp7a^Mo-brJ/Atp7a⁺ Mt1^tm1Bri/Mt1^tm1Bri Mt2^tm1Bri/Mt2^tm1Bri Tg(Mt1)174Bri/0
Genetic Background	involves: 129S7/SvEvBrd * C3H/HeJ * C57BL/6 * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:33276 )

• mice are phenotypically normal

Allelic Composition	Atp7a^Mo-brJ/Y Mt1^tm1Bri/Mt1^tm1Bri Mt2^tm1Bri/Mt2^tm1Bri
Genetic Background	involves: 129S7/SvEvBrd * C3H/HeJ * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:33276 )

• no mice are recovered at P9

embryonic lethality during organogenesis, incomplete penetrance ( J:33276 )

• only one mouse was recovered at E11

cellular

increased sensitivity to induced cell death ( J:33276 )

• cells from E11 embryos exhibit increased cell death when cultured with copper compared with similarly treated heterozygous cells

Allelic Composition	Atp7a^Mo-brJ/Y
Genetic Background	involves: C3H/HeJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp7a^Mo-brJ mutation (0 available); any Atp7a mutation (69 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality ( J:33276 )

• mice die around 2 weeks after birth

• mice cannot be rescued by perinatal copper injection therapy as can hemizygous Atp7a^Mo-brJ mice

homeostasis/metabolism

increased intestine copper level ( J:33276 )

• copper accumulates in the intestine

• however, kidney and brain copper levels are normal

decreased liver copper level ( J:33276 )

liver/biliary system

decreased liver copper level ( J:33276 )

pigmentation

abnormal coat/hair pigmentation ( J:33276 )

mottled coat ( J:33276 )

• sooty gray-white in color due to deficiency of the copper-dependent tyrosinase enzyme

behavior/neurological

tremors ( J:33276 )

abnormal gait ( J:33276 )

• uncoordinated

integument

abnormal coat/hair pigmentation ( J:33276 )

mottled coat ( J:33276 )

• sooty gray-white in color due to deficiency of the copper-dependent tyrosinase enzyme

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