Phenotypes associated with this allele
Allelic Composition |
Atp7aMo-ms/Atp7a+
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Genetic Background |
Not Specified |
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp7aMo-ms mutation
(0 available);
any
Atp7a mutation
(69 available)
|
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integument
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• mice exhibit mutant hair arranged in an irregular pattern of transverse bars compared with wild-type mice
• however, coat color is normal
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• postnatally, but straightened in adults
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Allelic Composition |
Atp7aMo-ms/Y
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Genetic Background |
involves: CBA |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp7aMo-ms mutation
(0 available);
any
Atp7a mutation
(69 available)
|
|
|
homeostasis/metabolism
renal/urinary system
Allelic Composition |
Atp7aMo-ms/Y
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Genetic Background |
involves: CBA/Kw |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp7aMo-ms mutation
(0 available);
any
Atp7a mutation
(69 available)
|
|
|
mortality/aging
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• average life span is 16 days
• life span is influenced by genetic background of fostering dam
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homeostasis/metabolism
integument
behavior/neurological
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• paresis in the hindlimb beginning at day 8
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growth/size/body
liver/biliary system
nervous system
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• copper levels in the brain are less than in wild-type mice
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Allelic Composition |
Atp7aMo-ms/Y
|
|
Genetic Background |
Not Specified |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp7aMo-ms mutation
(0 available);
any
Atp7a mutation
(69 available)
|
|
|
behavior/neurological
homeostasis/metabolism
integument
|
• mice exhibit abnormal pigmentation and hair structure of the vibrissae compared with wild-type mice
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liver/biliary system
mortality/aging
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• mice die between 2 and 3 weeks of age
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nervous system
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• arcuate nucleus growth hormone-releasing hormone (GHRH) neurons exhibit morphological changes associated with apoptosis unlike in wild-type mice
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pigmentation
cellular
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• arcuate nucleus growth hormone-releasing hormone (GHRH) neurons exhibit morphological changes associated with apoptosis unlike in wild-type mice
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