Phenotypes associated with this allele

• Allele Symbol: Edar^dl-J
• Allele Name: downless Jackson
• Allele ID: MGI:1856018
• Summary: 5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Edar^dl-J/Edar^dl-J	involves: C3HeB/FeJ	MGI:4889086
hm2	Edar^dl-J/Edar^dl-J	involves: FVB/N	MGI:4889103
ht3	Edar^dl-J/Edar^+	involves: C3HeB/FeJ	MGI:5484584
ht4	Edar^dl-J/Edar^tm1.1Bamo	involves: 129S4/SvJae * C3HeB/FeJ * FVB/N	MGI:5484585
ht5	Edar^dl-J/Edar^dl-3J	Not Specified	MGI:5638122

Genotype
MGI:4889086

hm1

• Allelic Composition: Edar^dl-J/Edar^dl-J
• Genetic Background: involves: C3HeB/FeJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

abnormal coat/ hair morphology ( J:5859 )

• only one type of hair is found resembling an abnormal awl

absent auchene hairs ( J:5859 )

abnormal awl hair morphology ( J:5859 )

• septa are irregular in shape and varied in number along the shaft with corresponding irregularities in calbre of the shaft

abnormal coat/hair pigmentation ( J:5859 )

darkened coat color ( J:5859 )

• the number of hairs with yellow banding is reduced in mice that are homozygous agouti resulting in a darker than expected coat

absent duvet hair ( J:5859 )

absent guard hair ( J:5859 )

pigmentation

abnormal coat/hair pigmentation ( J:5859 )

darkened coat color ( J:5859 )

• the number of hairs with yellow banding is reduced in mice that are homozygous agouti resulting in a darker than expected coat

Genotype
MGI:4889103

hm2

• Allelic Composition: Edar^dl-J/Edar^dl-J
• Genetic Background: involves: FVB/N

digestive/alimentary system

abnormal circumvallate papillae morphology ( J:168036 )

• the embryonic CVP is dysplastic, appearing as a downward fissure rather than a raised dome

abnormal minor salivary gland morphology ( J:168036 )

• histological indications of developing minor salivary glands in E15.5 embryos are absent

• exogenous Fgf8 and Shh do not fully rescue lingual gland development in E13.5 tongue explants after 4 days in culture

absent anterior lingual gland ( J:168036 )

• in adult mutant mice

absent palatine gland ( J:168036 )

• in adult mutant mice

endocrine/exocrine glands

abnormal minor salivary gland morphology ( J:168036 )

• histological indications of developing minor salivary glands in E15.5 embryos are absent

• exogenous Fgf8 and Shh do not fully rescue lingual gland development in E13.5 tongue explants after 4 days in culture

absent anterior lingual gland ( J:168036 )

• in adult mutant mice

absent palatine gland ( J:168036 )

• in adult mutant mice

absent Meibomian glands ( J:50575 )

absent sweat gland ( J:50575 )

• there are no sweat glands on the footpads

integument

absent Meibomian glands ( J:50575 )

absent sweat gland ( J:50575 )

• there are no sweat glands on the footpads

abnormal coat appearance ( J:50575 )

• mutant mice have only one hair type that appears intermediate between guard and awl forms

absent hair follicles ( J:50575 )

• hair is not found on the tail

craniofacial

abnormal enamel knot morphology ( J:148176 )

• due to failure of cell condensation, the molars of developing mice have "ropes" of enamel cells extending across the tooth primordium rather than a central signaling center or enamel knot

abnormal circumvallate papillae morphology ( J:168036 )

• the embryonic CVP is dysplastic, appearing as a downward fissure rather than a raised dome

growth/size/body

abnormal enamel knot morphology ( J:148176 )

• due to failure of cell condensation, the molars of developing mice have "ropes" of enamel cells extending across the tooth primordium rather than a central signaling center or enamel knot

abnormal circumvallate papillae morphology ( J:168036 )

• the embryonic CVP is dysplastic, appearing as a downward fissure rather than a raised dome

vision/eye

absent Meibomian glands ( J:50575 )

skeleton

abnormal enamel knot morphology ( J:148176 )

• due to failure of cell condensation, the molars of developing mice have "ropes" of enamel cells extending across the tooth primordium rather than a central signaling center or enamel knot

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hypohidrotic ectodermal dysplasia		DOID:14793		J:50575

Genotype
MGI:5484584

ht3

• Allelic Composition: Edar^dl-J/Edar⁺
• Genetic Background: involves: C3HeB/FeJ

endocrine/exocrine glands

decreased eccrine gland number ( J:193816 )

• subtle decrease in the number of glands per foot pad

integument

decreased eccrine gland number ( J:193816 )

• subtle decrease in the number of glands per foot pad

limbs/digits/tail

decreased eccrine gland number ( J:193816 )

• subtle decrease in the number of glands per foot pad

Genotype
MGI:5484585

ht4

• Allelic Composition: Edar^dl-J/Edar^tm1.1Bamo
• Genetic Background: involves: 129S4/SvJae * C3HeB/FeJ * FVB/N

endocrine/exocrine glands

increased eccrine gland number ( J:193816 )

• increase in the number of glands per foot pads compared to mice heterozygous for Edar^dl-J alone

integument

increased eccrine gland number ( J:193816 )

• increase in the number of glands per foot pads compared to mice heterozygous for Edar^dl-J alone

limbs/digits/tail

increased eccrine gland number ( J:193816 )

• increase in the number of glands per foot pads compared to mice heterozygous for Edar^dl-J alone

Genotype
MGI:5638122

ht5

• Allelic Composition: Edar^dl-J/Edar^dl-3J
• Genetic Background: Not Specified

pigmentation

abnormal coat/hair pigmentation ( J:43743 )

darkened coat color ( J:43743 )

• on an agouti background the number of hairs with yellow banding is reduced, producing a darker than expected coat color

integument

abnormal coat/ hair morphology ( J:43743 )

• only one type of hair

abnormal coat/hair pigmentation ( J:43743 )

darkened coat color ( J:43743 )

• on an agouti background the number of hairs with yellow banding is reduced, producing a darker than expected coat color