All Phenotypes Lyst<bg-Lac> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lyst^bg-Lac/Lyst^bg-Lac	CBA/CaLac-Lyst^bg-Lac	MGI:3784690
hm2	Lyst^bg-Lac/Lyst^bg-Lac	involves: CBA/CaLac	MGI:3848795

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

absent NK T cells ( J:29745 )

• no evidence of NK cells is observed

immune system

absent NK T cells ( J:29745 )

• no evidence of NK cells is observed

cellular

abnormal lysosome morphology ( J:29745 )

• large granules like those associated with Chediak-Higashi Syndrome are observed

craniofacial

decreased ear pigmentation ( J:29745 )

• pigmentation is reduced, much lighter than normal

hearing/vestibular/ear

decreased ear pigmentation ( J:29745 )

• pigmentation is reduced, much lighter than normal

limbs/digits/tail

decreased tail pigmentation ( J:29745 )

• pigmentation is reduced, appearing much lighter than normal

pigmentation

decreased ear pigmentation ( J:29745 )

• pigmentation is reduced, much lighter than normal

diluted coat color ( J:29745 )

• the coat appears grey on this background

decreased tail pigmentation ( J:29745 )

• pigmentation is reduced, appearing much lighter than normal

abnormal eye pigmentation ( J:29745 )

• eyes are light at birth, varying from ruby to almost black in adults

decreased eye pigmentation ( J:29745 )

vision/eye

abnormal eye pigmentation ( J:29745 )

• eyes are light at birth, varying from ruby to almost black in adults

decreased eye pigmentation ( J:29745 )

integument

decreased ear pigmentation ( J:29745 )

• pigmentation is reduced, much lighter than normal

diluted coat color ( J:29745 )

• the coat appears grey on this background

decreased tail pigmentation ( J:29745 )

• pigmentation is reduced, appearing much lighter than normal

growth/size/body

decreased ear pigmentation ( J:29745 )

• pigmentation is reduced, much lighter than normal

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Chediak-Higashi syndrome		DOID:2935	OMIM:214500	J:29745

Allelic Composition	Lyst^bg-Lac/Lyst^bg-Lac
Genetic Background	involves: CBA/CaLac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyst^bg-Lac mutation (0 available); any Lyst mutation (225 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

decreased ear pigmentation ( J:29745 )

• the ears are lighter than the expected agouti pigmentation

hearing/vestibular/ear

decreased ear pigmentation ( J:29745 )

• the ears are lighter than the expected agouti pigmentation

limbs/digits/tail

decreased tail pigmentation ( J:29745 )

• the tail is lighter than the expected agouti pigmentation

pigmentation

decreased ear pigmentation ( J:29745 )

• the ears are lighter than the expected agouti pigmentation

diluted coat color ( J:29745 )

• the coat appears grey on this agouti background

decreased tail pigmentation ( J:29745 )

• the tail is lighter than the expected agouti pigmentation

integument

decreased ear pigmentation ( J:29745 )

• the ears are lighter than the expected agouti pigmentation

diluted coat color ( J:29745 )

• the coat appears grey on this agouti background

decreased tail pigmentation ( J:29745 )

• the tail is lighter than the expected agouti pigmentation

growth/size/body

decreased ear pigmentation ( J:29745 )

• the ears are lighter than the expected agouti pigmentation

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/30/2024 MGI 6.23