Hddc3^tm1Jtchi
Targeted Allele Detail

Summary

• Symbol: Hddc3^tm1Jtchi
• Name: HD domain containing 3; targeted mutation 1, Jen-Tsan Chi
• MGI ID: MGI:8475090
• Synonyms: Mesh1^a
• Gene: Hddc3 Location: Chr7:79992852-80000295 bp, + strand Genetic Position: Chr7, 45.65 cM
• Alliance: Hddc3^tm1Jtchi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:393424
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details:

  Using a targeting vector from IKMC Project 92733, the L1L2_Bact_P cassette was inserted upstream of the critical exons 2 and 3. The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exons 2 and 3. The critical exons 2 and 3 are thus flanked by loxP sites. Absence of protein expression was confirmed in the heart, kidney and brain of homozygous mutant mice. (J:393424)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hddc3 Mutation: 14 strains or lines available

References

• Original: J:393424 Lin CC, et al., MESH1 functions as a metazoan PAPS phosphatase to regulate sulfation. Nat Chem Biol. 2026 Sep;22(9):1391-1399
• All: 1 reference(s)