Slc6a17^em2Yrao
Endonuclease-mediated Allele Detail

Summary

• Symbol: Slc6a17^em2Yrao
• Name: solute carrier family 6 (neurotransmitter transporter), member 17; endonuclease-mediated mutation 2, Yi Rao
• MGI ID: MGI:8472099
• Gene: Slc6a17 Location: Chr3:107374864-107425334 bp, - strand Genetic Position: Chr3, 46.83 cM, cytoband F2.3
• Alliance: Slc6a17^em2Yrao page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details:

  CRISPR/Cas9-mediated recombination using sgRNAs 5'-catgcccaggtaacacctatggg-3' and 5'-cctgttaacaacactatctgaca-3' deleted exon 2 that encodes the first 99 amino acids of the gene. (J:344886)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc6a17 Mutation: 34 strains or lines available

References

• Original: J:344886 Jia X, et al., Importance of glutamine in synaptic vesicles revealed by functional studies of SLC6A17 and its mutations pathogenic for intellectual disability. Elife. 2023 Jul 13;12
• All: 1 reference(s)