Zbtb7b^m1Pgrs
Chemically induced Allele Detail

Summary

• Symbol: Zbtb7b^m1Pgrs
• Name: zinc finger and BTB domain containing 7B; mutation 1, Philippe Gros
• MGI ID: MGI:8407069
• Synonyms: Zbtb7b^R367Q
• Gene: Zbtb7b Location: Chr3:89284953-89300976 bp, - strand Genetic Position: Chr3, 39.09 cM, cytoband A1-A2
• Alliance: Zbtb7b^m1Pgrs page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU) (Not Applicable)
• Mutation: Single point mutation
• Mutation details:

  ENU mutagenesis induced a G-to-A mutation changing arginine codon 367 (CGG) to glutamine (CAG) (p.R367Q). The mutation, in a zinc finger domain of the encoded protein, affects DNA binding and protects carriers against neuroinflammation in cerebral malaria but also leads to increased susceptibility to pulmonary tuberculosis. (J:284753)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zbtb7b Mutation: 28 strains or lines available

References

• Original: J:284753 Kennedy JM, et al., ZBTB7B (ThPOK) Is Required for Pathogenesis of Cerebral Malaria and Protection against Pulmonary Tuberculosis. Infect Immun. 2020 Jan 22;88(2)
• All: 1 reference(s)