Faah^tm2.1Crv
Targeted Allele Detail

Summary

• Symbol: Faah^tm2.1Crv
• Name: fatty acid amide hydrolase; targeted mutation 2.1, Benjamin F Cravatt
• MGI ID: MGI:8403735
• Synonyms: FAAH-S268D
• Gene: Faah Location: Chr4:115853866-115876034 bp, - strand Genetic Position: Chr4, 53.08 cM
• Alliance: Faah^tm2.1Crv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:282520
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted
• Mutation: Nucleotide substitutions
• Mutation details:

  Serine codon 268 (AGC) in exon 6 was changed to aspartic acid (GAC) (p.S268D) and an FRT site flanked neomycin resistance gene cassette was inserted into intron 7. The neo cassette was removed through subsequent Flp-mediated recombination. The mutation impairs the encoded protein's hydrolysis of N-acyl taurine (NAT) substrates but leaves N-acylethanolamine (NAE) hydrolysis intact. (J:282520)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Faah Mutation: 31 strains or lines available

References

• Original: J:282520 Grevengoed TJ, et al., N-acyl taurines are endogenous lipid messengers that improve glucose homeostasis. Proc Natl Acad Sci U S A. 2019 Dec 3;116(49):24770-24778
• All: 1 reference(s)