Gbx1^{tm1.1(icre)Uze}
Targeted Allele Detail

Summary

• Symbol: Gbx1^{tm1.1(icre)Uze}
• Name: gastrulation brain homeobox 1; targeted mutation 1.1, University of Zurich
• MGI ID: MGI:8402537
• Synonyms: Gbx1^iCre
• Gene: Gbx1 Location: Chr5:24709424-24731846 bp, - strand Genetic Position: Chr5, 11.93 cM
• Alliance: Gbx1^{tm1.1(icre)Uze} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:389394
• Parent Cell Line: JM8.N4 (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Gbx1^{tm1.1(icre)Uze} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Gbx1 (MGI:95667)

• Mutation details:

  A targeting construct was designed to insert an internal ribosome entry site (IRES), a codon-improved icre sequence, followed by a BGH pA signal, and a frt-flanked neomycin resistance (neo) cassette into the 3' UTR of the gastrulation brain homeobox 1 (Gbx1) gene. FLPe recombinase removed the frt-flanked neomycin resistance (neo) cassette. (J:101977, J:389394)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Gbx1 (mouse) Summary of all recombinase alleles driven by Gbx1. Alliance mouse Gbx1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gbx1 Mutation: 20 strains or lines available

References

• Original: J:389394 Haenraets K, et al., GABAergic Gbx1 neurons of the superficial dorsal horn are critical elements of a spinal circuit for stress-induced analgesia. Neuron. 2026 Mar 16
• All: 2 reference(s)