Nrxn3^{rs241832271-T}
Spontaneous Allele Detail

Summary

• Symbol: Nrxn3^{rs241832271-T}
• Name: neurexin III; rs241832271 SNP allele with the T variant
• MGI ID: MGI:8395583
• Gene: Nrxn3 Location: Chr12:88689646-90301709 bp, + strand Genetic Position: Chr12, 42.94 cM
• Alliance: Nrxn3^{rs241832271-T} page

Mutation origin

• Strain of Origin: 129S1/SvImJ

Mutation description

• Allele Type: Spontaneous (Not Applicable)
• Mutation: Single point mutation
• Mutation details:

  A spontaneous C-to-T mutation in exon 6 changes arginine codon 498 (CGG) to tryptophan (TGG) (p.R498W). This variant, in the highly conserved in the third extra-cellular LNS (laminin-neurexin-sex hormone binding globulin) domain of the encoded protein, is found in the 129S1 strain (all other sequenced strains have the C variant) and leads to enhanced empathy fear. (J:269348)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nrxn3 Mutation: 81 strains or lines available

References

• Original: J:269348 Keum S, et al., A Missense Variant at the Nrxn3 Locus Enhances Empathy Fear in the Mouse. Neuron. 2018 May 2;98(3):588-601.e5
• All: 1 reference(s)