Naxd^em#Ihj
Endonuclease-mediated Allele Detail

Summary

• Symbol: Naxd^em#Ihj
• Name: NAD(P)HX dehydratase; endonuclease-mediated mutation, Isha H Jain
• MGI ID: MGI:8394071
• Gene: Naxd Location: Chr8:11547506-11563287 bp, + strand Genetic Position: Chr8, 5.73 cM, cytoband A2
• Alliance: Naxd^em#Ihj page

Mutation origin

• Strain of Origin: C57BL/6NJ

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details:

  CRISPR/Cas9-mediated recombination using crRNA 5'-TCTGACGTCGAAGAAGCACA-3' targeting exon 2 introduced frameshift mutations resulting in 1-, 2-, or 4-bp deletions. These independent lines were used interchangeably. The pound symbol (#) is used when line is not specified and/or lines are pooled. (J:389717)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Naxd Mutation: 21 strains or lines available

References

• Original: J:389717 Garg A, et al., Vitamin B2 and B3 nutrigenomics reveals a therapy for NAXD disease. Cell. 2026 Feb 25
• All: 1 reference(s)