Cic^em1Hzo
Endonuclease-mediated Allele Detail

Summary

• Symbol: Cic^em1Hzo
• Name: capicua transcriptional repressor; endonuclease-mediated mutation 1, Huda Y Zoghbi
• MGI ID: MGI:8353676
• Gene: Cic Location: Chr7:24967129-24993584 bp, + strand Genetic Position: Chr7, 13.73 cM
• Alliance: Cic^em1Hzo page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: 1975 bp segment in exon 2 of the mouse Cic gene (ENSMUST00000169266.8) was deleted using CRISPR/cas9-mediated gene editing (crRNAs: 5'- CGCACCTGGCGCACGACTGC-3' and 5'-TCCAGCCGCACCGACTGCTG-3') in C57BL/6J embryos. This mutation creates a frameshift knock-out of the CIC-L (long) isoform of Cic. (J:101977)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cic Mutation: 99 strains or lines available

References

• Original: J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017
• All: 1 reference(s)