Mbnl1^em1Coop
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mbnl1^em1Coop
• Name: muscleblind like splicing regulator 1; endonuclease-mediated mutation 1, Thomas A Cooper
• MGI ID: MGI:8350476
• Synonyms: Mbnl1^flox
• Gene: Mbnl1 Location: Chr3:60380251-60537171 bp, + strand Genetic Position: Chr3, 29.17 cM, cytoband E1
• Alliance: Mbnl1^em1Coop page

Mutation origin

• Strain of Origin: C57BL/6NJ

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready)
• Mutation: Insertion
• Mutation details: Exon 3 (1,049 bp) that contains the translational start site was flanked by loxP sites via CRISPR/Cas9 mediated recombination. (J:386516)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mbnl1 Mutation: 39 strains or lines available

References

• Original: J:386516 Peterson JAM, et al., MBNL loss of function in smooth muscle as a model for myotonic dystrophy associated gastrointestinal dysmotility. Proc Natl Acad Sci U S A. 2025 Dec 16;122(50):e2522788122
• All: 1 reference(s)