Smad3^tm1.1Takm
Targeted Allele Detail

Summary

• Symbol: Smad3^tm1.1Takm
• Name: SMAD family member 3; targeted mutation 1.1, Takeshi Miyamoto
• MGI ID: MGI:8347622
• Gene: Smad3 Location: Chr9:63554049-63665276 bp, - strand Genetic Position: Chr9, 34.22 cM, cytoband D
• Alliance: Smad3^tm1.1Takm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:316329
• Parent Cell Line: B6-3i/HK3i (ES Cell)
• Strain of Origin: C57BL/6NJcl

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting construct floxed exons 2 and 3. Flp-mediated recombination removed the selection cassette. (J:316329)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Smad3 Mutation: 22 strains or lines available

References

• Original: J:316329 Umezu T, et al., Smad2 and Smad3 expressed in skeletal muscle promote immobilization-induced bone atrophy in mice. Biochem Biophys Res Commun. 2021 Dec 10;582:111-117
• All: 1 reference(s)