Mapt^{em12(MAPT*)Tcs}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mapt^{em12(MAPT*)Tcs}
• Name: microtubule-associated protein tau; endonuclease-mediated mutation 12, Takaomi Saido
• MGI ID: MGI:8347565
• Synonyms: Mapt^{em(MAPT/P301L; Inton10+3 G}A)Tcs>
• Gene: Mapt Location: Chr11:104122216-104222916 bp, + strand Genetic Position: Chr11, 67.79 cM, cytoband E1
• Alliance: Mapt^{em12(MAPT*)Tcs} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:362504
• Parent Cell Line: iTL BA1 (ES Cell)
• Strain of Origin: (C57BL/6NTac x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Endonuclease-mediated (Inserted expressed sequence)
• Mutation: Insertion
• Mapt^{em12(MAPT*)Tcs} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MAPT (4137)

  Mapt	(MGI:97180)

  mutant

• CRISPR-targeting replaced the mouse gene with a modified human gene (MAPT/P301L; Inton10+3 G>A). (J:362504)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mapt Mutation: 457 strains or lines available

References

• Original: J:362504 Watamura N, et al., In vivo hyperphosphorylation of tau is associated with synaptic loss and behavioral abnormalities in the absence of tau seeds. Nat Neurosci. 2025 Feb;28(2):293-307
• All: 2 reference(s)