Kmt2c^em1Atkt
Endonuclease-mediated Allele Detail

Summary

• Symbol: Kmt2c^em1Atkt
• Name: lysine (K)-specific methyltransferase 2C; endonuclease-mediated mutation 1, Atsushi Takata
• MGI ID: MGI:8347557
• Synonyms: Kmt2c^em1AtktTkato, Kmt2c^fs
• Gene: Kmt2c Location: Chr5:25476796-25703781 bp, - strand Genetic Position: Chr5, 12.35 cM
• Alliance: Kmt2c^em1Atkt page

Mutation origin

• Strain of Origin: C57BL/6NJcl

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR/Cas-mediated targeting of exon 43 deleted 19 bp and resulted in a frameshift allele. (J:368607)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kmt2c Mutation: 182 strains or lines available

References

• Original: J:368607 Nakamura T, et al., Transcriptomic dysregulation and autistic-like behaviors in Kmt2c haploinsufficient mice rescued by an LSD1 inhibitor. Mol Psychiatry. 2024 Sep;29(9):2888-2904
• All: 2 reference(s)