Kat5^tm1.1Rbrc
Targeted Allele Detail

Summary

• Symbol: Kat5^tm1.1Rbrc
• Name: K(lysine) acetyltransferase 5; targeted mutation 1.1, RIKEN BioResource Center
• MGI ID: MGI:8347554
• Gene: Kat5 Location: Chr19:5653042-5660265 bp, - strand Genetic Position: Chr19, 4.34 cM
• Alliance: Kat5^tm1.1Rbrc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:281982
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting construct introduced immediately upstream of exon 3 an FRT-flanked puromycin resistance cassette with a 3' loxP site and immediately downstream of exon 11 an FRT-flanked neomycin resistance cassette with a 5' loxP site. Flp-mediated recombination removed the selection cassettes and left exons 3 through 11 floxed. (J:281982)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kat5 Mutation: 28 strains or lines available

References

• Original: J:281982 Hishikawa A, et al., Decreased KAT5 Expression Impairs DNA Repair and Induces Altered DNA Methylation in Kidney Podocytes. Cell Rep. 2019 Jan 29;26(5):1318-1332.e4
• All: 2 reference(s)