Il7r^{em1(cre/ERT2)Lto}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Il7r^{em1(cre/ERT2)Lto}
• Name: interleukin 7 receptor; endonuclease-mediated mutation 1, Toshiaki Ohteki
• MGI ID: MGI:8347550
• Gene: Il7r Location: Chr15:9505874-9530262 bp, - strand Genetic Position: Chr15, 4.16 cM
• Alliance: Il7r^{em1(cre/ERT2)Lto} page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Il7r^{em1(cre/ERT2)Lto} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Il7r (MGI:96562)

• Mutation details: CRISPR/Cas-mediated recombination introduced an inducible cre recombinase fusion gene (cre/ERT2) near the termination sequence. (J:369569)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Il7r (mouse) Summary of all recombinase alleles driven by Il7r. Alliance mouse Il7r gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il7r Mutation: 37 strains or lines available

References

• Original: J:369569 Kanayama M, et al., Diverse developmental pathways of lymphoid conventional dendritic cells with distinct tissue distribution and function. Sci Adv. 2025 Jun 6;11(23):eadt4909
• All: 1 reference(s)