Runx1t1^M1
Chemically induced Allele Detail

Summary

• Symbol: Runx1t1^M1
• Name: RUNX1 translocation partner 1; mutation 1
• MGI ID: MGI:8345744
• Synonyms: Runx1t1^Y534H
• Gene: Runx1t1 Location: Chr4:13743436-13893649 bp, + strand Genetic Position: Chr4, 5.88 cM, cytoband A
• Alliance: Runx1t1^M1 page

Mutation origin

• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Chemically induced (ENU) (Not Applicable)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis in a 129X1/SvJ-Tg(Th-MYCN)41Waw strain created a GRCm39:chr4:13889672T>C mutation leading to the change of tyrosine codon 534 (TAC) to histidine (CAC) (ENSMUSP00000127109:p.Y534H). In heterozygous form, the mutation, in the NHR4 motif in the MYND zinc-finger domain of the encoded protein, suppresses development of MYCN-driven neuroblastomas on a 129X1/SvJ background. (J:351291)
• Inheritance: Dominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Runx1t1 Mutation: 37 strains or lines available

References

• Original: J:351291 Murray JE, et al., The transcriptional co-repressor Runx1t1 is essential for MYCN-driven neuroblastoma tumorigenesis. Nat Commun. 2024 Jul 11;15(1):5585
• All: 1 reference(s)