Irx1^{em1(cre/ERT2)Maoc}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Irx1^{em1(cre/ERT2)Maoc}
• Name: Iroquois homeobox 1; endonuclease-mediated mutation 1, Chai-An Mao
• MGI ID: MGI:8331905
• Synonyms: Irx1^{HA3-P2ACreERT2}
• Gene: Irx1 Location: Chr13:72106351-72111842 bp, - strand Genetic Position: Chr13, 38.43 cM
• Alliance: Irx1^{em1(cre/ERT2)Maoc} page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Irx1^{em1(cre/ERT2)Maoc} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Irx1 (MGI:1197515)

• Mutation details:

  CRISPR/Cas-mediated targeting inserted the synthetic HA3-P2A-CreERT2 DNA fragment in the c-terminal end in-frame with the last translation codon. (J:380949)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Irx1 (mouse) Summary of all recombinase alleles driven by Irx1. Alliance mouse Irx1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Irx1 Mutation: 22 strains or lines available

References

• Original: J:380949 Kiyama T, et al., Tbr2-dependent parallel pathways regulate the development of distinct ipRGC subtypes. Commun Biol. 2026 Feb 1;9(1)
• All: 1 reference(s)