Il2rg^em1Gmcr
Endonuclease-mediated Allele Detail

Summary

• Symbol: Il2rg^em1Gmcr
• Name: interleukin 2 receptor, gamma chain; endonuclease-mediated mutation 1, Gemcro Inc
• MGI ID: MGI:8322627
• Gene: Il2rg Location: ChrX:100307991-100311861 bp, - strand Genetic Position: ChrX, 43.9 cM
• Alliance: Il2rg^em1Gmcr page

Mutation origin

• Strain of Origin: NOD/ShiLtJ

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details:

  Using CRISPR technology, promoter and exon 8 of the endogenous Il2rg gene were targeted to delete the Il2rg gene. (J:101977, J:383195)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Il2rg Mutation: 140 strains or lines available

References

• Original: J:383195 Kim YM, et al., Generation of NOD SCID mice with near-complete deletions of Il2rg and Prkdc for human cancer and HSC engraftment. Transgenic Res. 2025 Jul 11;34(1):35
• All: 2 reference(s)