Psme3^em1Jinli
Endonuclease-mediated Allele Detail

Summary

• Symbol: Psme3^em1Jinli
• Name: proteaseome (prosome, macropain) activator subunit 3 (PA28 gamma, Ki); endonuclease-mediated mutation 1, Jing Li
• MGI ID: MGI:8318862
• Synonyms: PA28gamma^T23A
• Gene: Psme3 Location: Chr11:101207039-101214363 bp, + strand Genetic Position: Chr11, 64.67 cM
• Alliance: Psme3^em1Jinli page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Single point mutation
• Mutation details: Threonine codon 23 (ACA) in exon 2 was changed to alanine (GCA) (p.T23A) using an sgRNA and an ssODN template with CRISPR/Cas9 technology. In the encoded protein the mutation changes a phosphorylatable residue to one that cannot be phosphorylated. (J:378349)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Psme3 Mutation: 18 strains or lines available

References

• Original: J:378349 Sun S, et al., Phosphorylation of PA28gamma by CK2 kinase facilitates HNSCC tumor formation and progression. Nat Commun. 2025 Dec 10;17(1):443
• All: 1 reference(s)