Cabp7^tm1.1Yyam
Targeted Allele Detail

Summary

• Symbol: Cabp7^tm1.1Yyam
• Name: calcium binding protein 7; targeted mutation 1.1, Yuji Yamanashi
• MGI ID: MGI:8317207
• Synonyms: Cabp7^flox
• Gene: Cabp7 Location: Chr11:4686892-4696778 bp, - strand Genetic Position: Chr11, 2.98 cM
• Alliance: Cabp7^tm1.1Yyam page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:345130
• Parent Cell Line: JM8 (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A KOMP targeting vector used to create this conditional-ready allele. The vector places an FRT site, splice acceptor site, IRES, lacZ cassette, loxP site, neomycin resistance gene cassette, second FRT site and second loxP site into intron 1 and a third loxP site into intron 5. The lacZ sequence and neomycin resistance gene were removed via flp-mediated recombination leaving exons 2-5 floxed. (J:345130)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cabp7 Mutation: 16 strains or lines available

References

• Original: J:345130 Eguchi T, et al., Calcium-binding protein 7 expressed in muscle negatively regulates age-related degeneration of neuromuscular junctions in mice. iScience. 2024 Feb 16;27(2):108997
• All: 1 reference(s)