Brd4^tm2Dey
Targeted Allele Detail

Summary

• Symbol: Brd4^tm2Dey
• Name: bromodomain containing 4; targeted mutation 2, Anup Dey
• MGI ID: MGI:8296235
• Gene: Brd4 Location: Chr17:32415248-32503696 bp, - strand Genetic Position: Chr17, 17.39 cM, cytoband B2
• Alliance: Brd4^tm2Dey page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:268423
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• The targeting construct replaced exon 3 with a neomycin resistance cassette. (J:111726, J:268423)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Brd4 Mutation: 110 strains or lines available

References

• Original: J:268423 Inamochi Y, et al., Transcription elongation factor Brd4-P-TEFb accelerates intestinal differentiation-associated SLC2A5 gene expression. Biochem Biophys Rep. 2016 Sep;7:150-156
• All: 4 reference(s)