Gt(ROSA)26Sor^{tm1(PRCC/TFE3)Wml}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(PRCC/TFE3)Wml}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, W Marston Linehan
• MGI ID: MGI:8293370
• Synonyms: PRCC-TFE3, PRCC-TFE3^LSL
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(PRCC/TFE3)Wml} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:277665
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Humanized sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(PRCC/TFE3)Wml} expresses 2 genes
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  PRCC (5546)

  Prcc	(MGI:2137738)

  exon 1

  human

  TFE3 (7030)

  Tfe3	(MGI:98511)

  exons 4 - 10

• Gt(ROSA)26Sor^{tm1(PRCC/TFE3)Wml} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Gt(ROSA)26Sor (MGI:104735)

• Mutation details: A construct containing a floxed stop cassette and a cDNA consisting of a fusion of first exon of human PRCC and exons 4-10 of human TFE3 was inserted via homologous recombination. (J:277665)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1214 strains or lines available

References

• Original: J:277665 Baba M, et al., TFE3 Xp11.2 Translocation Renal Cell Carcinoma Mouse Model Reveals Novel Therapeutic Targets and Identifies GPNMB as a Diagnostic Marker for Human Disease. Mol Cancer Res. 2019 Aug;17(8):1613-1626
• All: 2 reference(s)