Gabarapl1^em#Lmdd
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gabarapl1^em#Lmdd
• Name: GABA type A receptor associated protein like 1; endonuclease-mediated mutation, Lea M D Delbridge
• MGI ID: MGI:8292204
• Gene: Gabarapl1 Location: Chr6:129510155-129519294 bp, + strand Genetic Position: Chr6, 63.39 cM
• Alliance: Gabarapl1^em#Lmdd page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology deleted exons 2-4. This record represents a pool of deletion alleles encompassing exons 2-4 from eight independent founder lines. Two of these alleles have an additional single nucleotide change and one allele has 8 bp with a single nucleotide change present in the deleted region. Phenotypic assessment was done on the pooled alleles. (J:378594)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gabarapl1 Mutation: 15 strains or lines available

References

• Original: J:378594 Mellor KM, et al., Targeted glycophagy ATG8 therapy reverses diabetic heart disease in mice and in human engineered cardiac tissues. Nat Cardiovasc Res. 2025 Nov;4(11):1487-1500
• All: 1 reference(s)