Srl^em1Flc
Endonuclease-mediated Allele Detail

Summary

• Symbol: Srl^em1Flc
• Name: sarcalumenin; endonuclease-mediated mutation 1, Frank Conlon
• MGI ID: MGI:8292131
• Synonyms: Srl-flox
• Gene: Srl Location: Chr16:4298080-4359680 bp, - strand Genetic Position: Chr16, 2.44 cM
• Alliance: Srl^em1Flc page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details:

  CRISPR-targeting floxed the 5 end of the gene (encompassing the promoter) and the 1st exon are flanked by loxP sites. (J:361598)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Srl Mutation: 51 strains or lines available

References

• Original: J:361598 Emerson JI, et al., X-Chromosome-Linked miRNAs Regulate Sex Differences in Cardiac Physiology. Circ Res. 2025 Jan 31;136(3):258-275
• All: 1 reference(s)