Gt(ROSA)26Sor^{tm1(Sox2)Olvr}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(Sox2)Olvr}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Trudy Oliver
• MGI ID: MGI:8291645
• Synonyms: Rosa26^{LSL-Sox2-IRES-GFP}, Sox2^LSL-IRES-GFP
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(Sox2)Olvr} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:278145
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, Reporter)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(Sox2)Olvr} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  Not Specified	Sox2

• A construct containing a floxed STOP cassette, Sox2 cDNA, IRES, and GFP was inserted in the locus. (J:278145)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1206 strains or lines available

References

• Original: J:278145 Mollaoglu G, et al., The Lineage-Defining Transcription Factors SOX2 and NKX2-1 Determine Lung Cancer Cell Fate and Shape the Tumor Immune Microenvironment. Immunity. 2018 Oct 16;49(4):764-779.e9
• All: 2 reference(s)