Nanog^{tm1.1(cre/ERT2)Jhha}
Targeted Allele Detail

Summary

• Symbol: Nanog^{tm1.1(cre/ERT2)Jhha}
• Name: Nanog homeobox; targeted mutation 1.1, Jacob Hanna
• MGI ID: MGI:8290832
• Synonyms: Nanog-CreER
• Gene: Nanog Location: Chr6:122684448-122691592 bp, + strand Genetic Position: Chr6, 57.8 cM, cytoband F2
• Alliance: Nanog^{tm1.1(cre/ERT2)Jhha} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:379979
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Nanog^{tm1.1(cre/ERT2)Jhha} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Nanog (MGI:1919200)

• Mutation details: A knock-in tamoxifen-inducible CreER -frt-flanked hygromycin resistance cassette was inserted under the control of the endogenous gene promoter. Flp-mediated recombination in the gremline removed the inverted hygromycin-resistance cassette. (J:379979)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Nanog (mouse) Summary of all recombinase alleles driven by Nanog. Alliance mouse Nanog gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nanog Mutation: 48 strains or lines available

References

• Original: J:379979 Maza I, et al., Transient acquisition of pluripotency during somatic cell transdifferentiation with iPSC reprogramming factors. Nat Biotechnol. 2015 Jul;33(7):769-74
• All: 1 reference(s)