Alx1^em2Jian
Endonuclease-mediated Allele Detail

Summary

• Symbol: Alx1^em2Jian
• Name: ALX homeobox 1; endonuclease-mediated mutation 2, Rulang Jiang
• MGI ID: MGI:8290435
• Synonyms: Alx1^c
• Gene: Alx1 Location: Chr10:102834564-102865501 bp, - strand Genetic Position: Chr10, 53.56 cM
• Alliance: Alx1^em2Jian page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready)
• Mutation: Insertion
• Mutation details:

  Using CRISPR/Cas9 endonuclease-mediated genome editing, guide RNAs (GTAAGATGTGGGTGGTACT and GTGTGGTCAGTGATGACAAG) were used to introduce loxP sites flanking exon 2 of the ALX homeobox 1 (Alx1) gene. (J:94077, J:379587)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Alx1 Mutation: 23 strains or lines available

References

• Original: J:379587 Iyyanar PPR, et al., The ALX1 transcription factor acts in the early cranial mesoderm to specify extraocular muscle formation. Dis Model Mech. 2026 Feb 1;19(2):dmm052241
• All: 2 reference(s)