Plekhg1^em1(flpo)Pic
Endonuclease-mediated Allele Detail

Summary

• Symbol: Plekhg1^em1(flpo)Pic
• Name: pleckstrin homology domain containing, family G (with RhoGef domain) member 1; endonuclease-mediated mutation 1, Jim Pickel
• MGI ID: MGI:8290422
• Synonyms: Plekhg1-2A-FlpO
• Gene: Plekhg1 Location: Chr10:3690364-3917303 bp, + strand Genetic Position: Chr10, 2.06 cM
• Alliance: Plekhg1^em1(flpo)Pic page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Recombinase)
• Mutation: Insertion
• Plekhg1^em1(flpo)Pic expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Plekhg1 (MGI:2676551)

• CRISPR/Cas9 genome editing technology was used to insert a 2a-FlpO cassette into the gene. (J:259969)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Plekhg1 (mouse) Summary of all recombinase alleles driven by Plekhg1. Alliance mouse Plekhg1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Plekhg1 Mutation: 64 strains or lines available

References

• Original: J:259969 Wu Y, et al., Characterization of knockin mice at the Rosa26, Tac1 and Plekhg1 loci generated by homologous recombination in oocytes. PLoS One. 2018;13(2):e0193129
• All: 1 reference(s)