Mapt^{tm5(flpo)Arbr}
Targeted Allele Detail

Summary

• Symbol: Mapt^{tm5(flpo)Arbr}
• Name: microtubule-associated protein tau; targeted mutation 5, Silvia Arber
• MGI ID: MGI:8290412
• Synonyms: Tau^{lox-STOP-lox-FLP-INLA}, Tau^lsl-FLP
• Gene: Mapt Location: Chr11:104122216-104222916 bp, + strand Genetic Position: Chr11, 67.79 cM, cytoband E1
• Alliance: Mapt^{tm5(flpo)Arbr} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:205554
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Recombinase, Reporter)
• Mutation: Insertion
• Mapt^{tm5(flpo)Arbr} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Mapt (MGI:97180)

• Mutation details: A cassette containing a lox-STOP-lox-FLPo-IRES-Nls-LacZ-pA targeting cassette was integrated into exon 2. (J:205554)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Mapt (mouse) Summary of all recombinase alleles driven by Mapt. Alliance mouse Mapt gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mapt Mutation: 453 strains or lines available

References

• Original: J:205554 Pivetta C, et al., Motor-circuit communication matrix from spinal cord to brainstem neurons revealed by developmental origin. Cell. 2014 Jan 30;156(3):537-48
• All: 5 reference(s)