Nectin1^em1Yutom
Endonuclease-mediated Allele Detail

Summary

• Symbol: Nectin1^em1Yutom
• Name: nectin cell adhesion molecule 1; endonuclease-mediated mutation 1, Yukiko Tomioka
• MGI ID: MGI:8286389
• Synonyms: nectin-1 F129A
• Gene: Nectin1 Location: Chr9:43655251-43718758 bp, + strand Genetic Position: Chr9, 24.42 cM, cytoband B
• Alliance: Nectin1^em1Yutom page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details: Phenylalanine codon 129 (TTC) was changed to alanine (GCC) (c. 385-386delTTinsGC, p.F129A) using an sgRNA and an ssODN template with CRISPR/Cas9 technology. The mutation protects the mice from lethal pseudorabies virus (PRV) infections in a virus-titer-dependent manner. (J:355676)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nectin1 Mutation: 22 strains or lines available

References

• Original: J:355676 Tomioka Y, et al., Single amino acid mutation of nectin-1 provides remarkable resistance against lethal pseudorabies virus infection in mice. J Vet Med Sci. 2024 Jan 26;86(1):120-127
• All: 1 reference(s)