Hnf1a^tm1.1Schra
Targeted Allele Detail

Summary

• Symbol: Hnf1a^tm1.1Schra
• Name: HNF1 homeobox A; targeted mutation 1.1, Simona Chera
• MGI ID: MGI:8280631
• Synonyms: Hnf1a^flox
• Gene: Hnf1a Location: Chr5:115087039-115109121 bp, - strand Genetic Position: Chr5, 55.99 cM, cytoband F
• Alliance: Hnf1a^tm1.1Schra page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:377209
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• The targeting construct floxed exon 4. Flp-mediated recombination removed the selection cassette. (J:377209)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hnf1a Mutation: 33 strains or lines available

References

• Original: J:377209 Mathisen AF, et al., The age-dependent regulation of pancreatic islet landscape is fueled by a HNF1a-immune signaling loop. Mech Ageing Dev. 2024 Aug;220:111951
• All: 1 reference(s)