Kdm2b^tm1.1Hko
Targeted Allele Detail

Summary

• Symbol: Kdm2b^tm1.1Hko
• Name: lysine (K)-specific demethylase 2B; targeted mutation 1.1, Haruhiko Koseki
• MGI ID: MGI:8280470
• Synonyms: Kdm2b^flox-JmJ
• Gene: Kdm2b Location: Chr5:123008727-123127333 bp, - strand Genetic Position: Chr5, 62.63 cM, cytoband F
• Alliance: Kdm2b^tm1.1Hko page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:372289
• Parent Cell Line: M1/M-1 (ES Cell)
• Strain of Origin: (129 x C57BL/6)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• A pair of loxP flank exon 7 and 8. Flp-mediated recombination removed the selection cassette. (J:372289)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kdm2b Mutation: 219 strains or lines available

References

• Original: J:372289 Kawamura YK, et al., Preventing CpG hypermethylation in oocytes safeguards mouse development. Dev Cell. 2025 Aug 29
• All: 1 reference(s)